Article

Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.

2022-07-07

Abstract excerpt

Autism Spectrum Disorder (ASD), like many neurodevelopmental disorders, has complex and varied etiologies. Advances in genome sequencing have identified multiple candidate genes associated with ASD, including dozens of missense and nonsense mutations in the NMDAR subunit GluN2B, encoded by GRIN2B . NMDARs are glutamate-gated ion channels with key synaptic functions in excitatory neurotransmission. How alterations...

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Literature Corpus work: 13079ef2-b281-5731-9013-ab7be8ed8869
DOI: 10.21203/rs.3.rs-1766152/v1

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