Article

NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models

2024-10-09

Abstract excerpt

N-methyl-D-aspartate receptors (NMDARs) are critical components of the mammalian central nervous system, involved in synaptic transmission, plasticity, and neurodevelopment. This review focuses on the structural and functional characteristics of NMDARs, with a particular emphasis on the GRIN2 subunits (GluN2A-D). The diversity of GRIN2 subunits, driven by alternative splicing and genetic variants, significantly im...

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Literature Corpus work: d641444f-4449-53b6-93b7-49cacb9784ff
DOI: 10.20944/preprints202410.0621.v1

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