Article
Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.
Human molecular genetics - 15 Jul 2015
Kozol Robert A, Cukier Holly N, Zou Bing, Mayo Vera, De Rubeis Silvia, Cai Guiqing, Griswold Anthony J, Whitehead Patrice L, Haines Jonathan L, Gilbert John R, Cuccaro Michael L, Martin Eden R, Baker James D, Buxbaum Joseph D, Pericak-Vance Margaret A, Dallman Julia E
Abstract excerpt
Despite significant progress in the genetics of autism spectrum disorder (ASD), how genetic mutations translate to the behavioral changes characteristic of ASD remains largely unknown. ASD affects 1-2% of children and adults, and is characterized by deficits in verbal and non-verbal communication, and social interactions, as well as the presence of repetitive behaviors and/or stereotyped interests. ASD is...
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