Article
Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880.
Behavioural brain research - 15 Mar 2017
Han Mei, Mejias Rebeca, Chiu Shu-Ling, Rose Rebecca, Adamczyk Abby, Huganir Richard, Wang Tao
Abstract excerpt
Glutamate receptor interacting proteins 1 and 2 (GRIP1/2) play an important role in regulating synaptic trafficking of AMPA receptor 2/3 (GluA2/3) and synaptic strength. Gain-of-function GRIP1 mutations are implicated in social behavioral deficits in autism. To study mechanisms of Grip1/2-mediated AMPA signaling in the regulation of social behaviors, we performed social behavioral testing on neuron-specific...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Autism Spectrum Disorder
- Carrier Proteins
- Corpus Striatum
- Frontal Lobe
- Intracellular Signaling Peptides and Proteins
- Male
- Mice, Knockout
- Nerve Tissue Proteins
- Neurons
- Phenotype
- Phosphorylation