Article

Disruption of <i>grin2A</i> , an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish

2025-05-10

Abstract excerpt

<h4>ABSTRACT</h4> N-methyl-D-aspartate receptors (NMDARs) control synaptic plasticity and brain development in a manner determined by receptor subunit composition. Pathogenic variants in GRIN2A gene, encoding the NMDAR GluN2A subunit, can cause gain or loss of function of receptors containing the affected subunit, and are associated with intellectual disability and epilepsy in patients. While in-vitro studies o...

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Literature Corpus work: 70db9dce-8233-563b-89e7-0c406d999afe
DOI: 10.1101/2025.05.09.651809

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