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Article

Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice.

PLoS biology - 1 Apr 2020

Shin Wangyong, Kim Kyungdeok, Serraz Benjamin, Cho Yi Sul, Kim Doyoun, Kang Muwon, Lee Eun-Jae, Lee Hyejin, Bae Yong Chul, Paoletti Pierre, Kim Eunjoon

Abstract excerpt

Extensive evidence links Glutamate receptor, ionotropic, NMDA2B (GRIN2B), encoding the GluN2B/NR2B subunit of N-methyl-D-aspartate receptors (NMDARs), with various neurodevelopmental disorders, including autism spectrum disorders (ASDs), but the underlying mechanisms remain unclear. In addition, it remains unknown whether mutations in GluN2B, which starts to be expressed early in development, induces early...

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Identifiers

PMID: 32353004
DOI: 10.1371/journal.pbio.3000717
PMCID: PMC7217483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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