Article

Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk Mutations

2024-01-20

Abstract excerpt

Hundreds of human mutations are linked to autism and related disorders, yet the functions of many of these mutated genes during vertebrate neurodevelopment are unclear. We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes. We observed baseline and stimulus-driven behavioral changes at larval stages, as w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dea342a4-1dfc-594a-ac28-55b4bf93bf8b
DOI: 10.1101/2024.01.18.576309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk MutationsDOI 10.1101/2024.01.18.576309Read

Assessment of autism zebrafish mutant models using a high-throughput larval phenotyping platformSemantic proximity Read

Disruptive CHD8 mutations define a subtype of autism early in development.Semantic proximity Read

Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.Semantic proximity Read

Advances in behavioral genetics: mouse models of autism.Semantic proximity Read

Deficiency of the <i>ywhaz</i> gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafishSemantic proximity Read

KMT2E haploinsufficiency manifests autistic-like phenotypes and amygdala abnormality in miceSemantic proximity Read

Functional Neurogenomics to Dissect Disease Mechanisms Across Models.Semantic proximity Read

Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functionsSemantic proximity Read

Zebrafish screen of schizophrenia risk genes reveals convergent dysregulation of cholesterol metabolismSemantic proximity Read

Development and Characterization of a larp7 Knockout Zebrafish Model for Alazami syndromeSemantic proximity Read

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity Read

Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.Semantic proximity Read