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Article

CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors.

Molecular autism - 1 Jan 2018

Liu Chun-Xue, Li Chun-Yang, Hu Chun-Chun, Wang Yi, Lin Jia, Jiang Yong-Hui, Li Qiang, Xu Xiu

Abstract excerpt

Background: Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism underlying SHANK3 deficiency resulting in ASD is not fully understood. Recently, the zebrafish has become an attractive organism to model ASD because of its high efficiency of genetic manipulation and robust behavioral phenotypes. The...

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Identifiers

PMID: 29619162
DOI: 10.1186/s13229-018-0204-x
PMCID: PMC5879542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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