Article

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

2022-11-19

Abstract excerpt

Reducing disparities is critical to promote equity of access to precision treatments for all patients with cancer. While socioenvironmental factors are a major driver behind such disparities, biological differences also are likely to contribute. The prioritization of cancer drug targets is foundational for drug discovery, yet whether ancestry-related signals in target discovery pipelines exist has not been systema...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dc2edf03-0b3c-5886-ba29-da35541c6257
DOI: 10.1101/2022.11.18.517155

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestriesDOI 10.1101/2022.11.18.517155Read

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries.Semantic proximity Read

Integrated cross-study datasets of genetic dependencies in cancerSemantic proximity Read

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.Semantic proximity Read

Comprehensive Genomic Dependency Landscape of Human Colon CancerSemantic proximity Read

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screensSemantic proximity Read

A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening dataSemantic proximity Read

Inferred Ancestral Origin of Cancer Cell Lines Associates with Differential Drug Response.Semantic proximity Read

Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical SafetySemantic proximity Read

Widespread impact of natural genetic variations in CRISPR/Cas9 outcomesSemantic proximity Read

Precision oncology and genetic ancestry: The science behind population-based cancer disparities.Semantic proximity Read

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.Semantic proximity Read

Justice in CRISPR/Cas9 Research and Clinical ApplicationsSemantic proximity Read