Article

Gene regulatory programs of cognitive resilience and pathogenesis in Alzheimer’s disease

2026-02-26

Abstract excerpt

<h4>INTRODUCTION</h4> Cognitive resilience in Alzheimer’s disease (AD), wherein individuals maintain cognition despite substantial neuropathology, implies protective regulatory programs that remain poorly characterized. <h4>METHODS</h4> We constructed a cell-type-resolved gene regulatory network atlas from 1.7 million nuclei across 687 individuals spanning 26 cell types in the dorsolateral prefrontal cortex, cla...

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Literature Corpus work: 12e5ab19-6975-5f92-841c-23154edb91c4
DOI: 10.64898/2026.02.19.26346666

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