Article

RIG-I-dependent tumor-intrinsic type I interferon signaling restricts growth in breast cancer 3D culture

2025-08-12

Abstract excerpt

Discovery of key growth drivers that can be targeted for therapy is a central goal in cancer research. While high-throughput CRISPR screens have revolutionized our ability to identify gene dependencies in cancer, most large-scale screens are conducted in two-dimensional (2D) culture systems that fail to recapitulate tumor organization and behavior. To uncover architecture-dependent vulnerabilities in breast cancer...

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Literature Corpus work: 12b10e1a-1beb-578f-8e16-5f329927a7e3
DOI: 10.1101/2025.08.10.669545

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