Article

Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids

2021-05-05

Abstract excerpt

<h4>Summary</h4> Cellular immunotherapies are rapidly gaining clinical importance, yet predictive platforms for modeling their mode of action are lacking. Here, we developed a dynamic immuno-organoid 3D imaging-transcriptomics platform; BEHAV3D, to unravel the behavioral and underlying molecular mechanisms of solid tumor targeting. Applied to an emerging cancer metabolome-sensing immunotherapy: TEGs, we first dem...

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Literature Corpus work: 79db4bee-5094-56be-97cf-11e8f8484a0c
DOI: 10.1101/2021.05.05.442764

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