Article

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejection

2022-12-22

Abstract excerpt

Targeting cytosolic nucleic acid sensors is a potent approach to drive type I interferon responses and anti-tumor immunity. Recent evidence suggests that activation of retinoic acid inducible gene-I (RIG-I) using synthetic hairpin RNA agonists decreases tumor progression in multiple preclinical models. However, the role of tumor cell intrinsic RIG-I in shaping tumor cell fates and the host immune microenvironment...

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Literature Corpus work: 10c22c3c-bf08-5a26-b53c-454c1f9ca119
DOI: 10.1101/2022.12.21.521495

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