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Article

Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer

14 Sept 2007

Abstract excerpt

BACKGROUND: Perturbations in cell-cell interactions are a key feature of cancer. However, little is known about the systematic effects of cell-cell interaction on global gene expression in cancer. RESULTS: We used an ex vivo model to simulate tumor-stroma interaction by systematically co-cultivating breast cancer cells with stromal fibroblasts and determined associated gene expression changes with cDNA...

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PMID: 17868458
DOI: 10.1186/gb-2007-8-9-r191

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