Article

Systematic Growth Factor Profiling Platform for 3D Tumor Models Reveals Estradiol-Responsive Cellular Mechanisms of Immunotherapy Resistance

2025-09-09

Abstract excerpt

Current organoid culture systems face critical limitations: standardized growth factor formulations fail to capture patient-specific signaling requirements, and single-cell-type approaches overlook tumor-stromal interactions essential for understanding immunotherapy resistance. To address these challenges, we developed an innovative biofabrication platform that systematically integrates patient-derived three-dimen...

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Literature Corpus work: ba96e4dc-98d7-545c-b885-ad5655c9ed7d
DOI: 10.1101/2025.09.04.674374

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