Article

DOT1L inhibition exerts anti-tumor effects by activating interferon signaling in breast cancer cells

2025-08-06

Abstract excerpt

<title>Abstract</title> <p>Background DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, is a potential therapeutic target in various malignancies. In the present study, we aimed to clarify the antitumor effect of DOT1L inhibition in breast cancer. Methods Estrogen receptor (ER)-positive/HER2-negative breast cancer cells (MCF7) and ER-negative/HER2-positive cells (SKBR3) were treated with a DOT1L inhibitor...

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Literature Corpus work: ad88f01d-fc37-56c0-8237-02ea3f94c179
DOI: 10.21203/rs.3.rs-6365502/v1

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