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Article

Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age.

Psychoneuroendocrinology - 1 Jan 2026

Lee Bonnie H, McGovern Andrew J, Lieblich Stephanie E, Mitchell Selene V, Yin Jie, Epp Jonathan R, Galea Liisa A M

Abstract excerpt

Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters biomarkers of brain health in middle age depending on Alzheimer's disease (AD) risk. This study investigated functional connectivity changes and network dynamics at middle age based on parity and APOEε4 genotype, the top genetic risk factor for late-onset sporadic AD...

Read the complete abstract on PubMed

Topics

Animals
Female
Male
Apolipoprotein E4
Rats
Genotype
Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pregnancy

Alzheimer Disease

Sex Factors

Parity

Aging

Sex Characteristics

Source

Identifiers

PMID: 41160972
DOI: 10.1016/j.psyneuen.2025.107655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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