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TAU FILAMENTS WITH THE CHRONIC TRAUMATIC ENCEPHALOPATHY FOLD IN A CASE OF VACUOLAR TAUOPATHY WITH <i>VCP</i> MUTATION D395G

2024-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant frontotemporal dementia, with marked vacuolation and abundant filamentous tau inclusions made of all six brain isoforms. Here we report that tau inclusions were concentrated in layers II/III of the frontotemporal cortex in a case of vacuolar tauopathy. By e...

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Literature Corpus work: 12a247d0-a373-5f0b-99fe-8eb9b9442333
DOI: 10.1101/2024.04.01.587539

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