Article

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction

2026-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The assembly of TAR DNA-binding protein 43 (TDP-43) into amyloid filaments within neurons is a hallmark of multiple neurodegenerative diseases, including motor neuron diseases (MND), frontotemporal dementias (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE). These diseases result from the deterioration and loss of neurons, with synaptic dysfunction and neuronal hyperexcitabil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74cb758a-cd61-5435-9931-6be540762ff5
DOI: 10.64898/2026.01.27.701787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunctionDOI 10.64898/2026.01.27.701787Read

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type CSemantic proximity Read

Structure of pathological TDP-43 filaments from ALS with FTLD.Semantic proximity Read

Structure-based Classification of TauopathiesSemantic proximity Read

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.Semantic proximity Read

Distinct tau filament folds in familial frontotemporal dementia due to the <i>MAPT</i> S305I mutationSemantic proximity Read

Tau filaments in neurodegenerative diseasesSemantic proximity Read

Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathySemantic proximity Read

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defectsSemantic proximity Read

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic FunctionsSemantic proximity Read

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.Semantic proximity Read

Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreadingSemantic proximity Read

Abnormal Tau-Containing Filaments in Neurodegenerative DiseasesSemantic proximity Read