Article
Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.
Acta neuropathologica - 17 May 2024
Qi Chao, Kobayashi Ryota, Kawakatsu Shinobu, Kametani Fuyuki, Scheres Sjors H W, Goedert Michel, Hasegawa Masato
Abstract excerpt
Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant frontotemporal dementia, with marked vacuolation and abundant filamentous tau inclusions made of all six brain isoforms. Here we report that tau inclusions were concentrated in layers II/III of the frontotemporal cortex in a case of vacuolar tauopathy. By electron...
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