Article

Quantitative prediction of variant effects on alternative splicing using endogenous pre-messenger RNA structure probing

2021-09-13

Abstract excerpt

Splicing is a highly regulated process that depends on numerous factors. It is particularly challenging to quantitatively predict how a mutation will affect precursor messenger RNA (mRNA) structure and the subsequent functional consequences. Here we use a novel Mutational Profiling (-MaP) methodology to obtain highly reproducible endogenous precursor and mature mRNA structural probing data in vivo. We use these da...

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Literature Corpus work: 1293fcc2-bbdb-5f7a-a0a3-c794ee70f00a
DOI: 10.1101/2021.09.13.460117

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