Article

CryoPhold: CryoEM meets AlphaFold and molecular simulation to reveal protein dynamics

2025-09-13

Abstract excerpt

Here we are introducing CryoPhold, a modular workflow that unifies AlphaFold-based ensemble generation, Bayesian reweighting against experimental cryo-EM maps, molecular simulation, and machine learning to quantify conformational populations and identify structural fingerprints that govern protein functions. Proteins are inherently dynamic, interconverting among conformational states that govern their function. Pe...

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Literature Corpus work: 8c4a2ef0-c0c0-56b6-acd9-d4fa2cf7339a
DOI: 10.1101/2025.09.12.675912

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