Article

Control of gene output by intron RNA structure

2025-11-09

Abstract excerpt

During mRNA biogenesis, RNA folding can promote or antagonize transcript processing. The effects of intron structure on mRNA and protein levels remain largely unexplored, although introns account for the bulk of nascent RNA. Here we systematically probe the effect of intron structure using massively parallel reporter assays. We show that base pairing modulates gene expression across orders of magnitude through inh...

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Literature Corpus work: 37735952-51a4-5564-bb1d-1678a8c20c64
DOI: 10.1101/2025.11.08.687378

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