Article

A Thermodynamic Theory of Splicing

2026-06-10

Abstract excerpt

<title>Abstract</title> <p>Splicing of pre-messenger RNA (pre-mRNA) to messenger RNA (mRNA) is a crucial step in protein synthesis (Gilbert, Nature 271 501, 1978) and is critical for the emergence of developmental complexity (Roca et al., Genes and Development 27, 129, 2013). Aberrant splicing causes many hereditary diseases including Parkinson's, cystic fibrosis, muscular dystrophy and some classes of cancer (Go...

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Literature Corpus work: 51e236f0-a2a2-5aa9-8ada-9261a649e2de
DOI: 10.21203/rs.3.rs-9751495/v1

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