Article

Interplay of primary sequence and RNA secondary structure in determining 5′ splice site choice

2018-07-24

Abstract excerpt

Selective use of 5′ splice sites is a common mechanism by which pre-mRNAs are alternatively spliced. Whereas the sequence requirements of 5′ splice site choice have been well characterized, other important determinants remain poorly defined. Here we apply a combination of structural mapping by SHAPE-MaP and targeted mutational analysis in a cell-based system to comprehensively probe the interplay of primary sequen...

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Literature Corpus work: e6d26d2c-3f06-5a36-894b-c75a85c363da
DOI: 10.1101/376343

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