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Article

Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure.

RNA (New York, N.Y.) - 1 Apr 2018

Lackey Lela, Coria Aaztli, Woods Chanin, McArthur Evonne, Laederach Alain

Abstract excerpt

The impact of inherited and somatic mutations on messenger RNA (mRNA) structure remains poorly understood. Recent technological advances that leverage next-generation sequencing to obtain experimental structure data, such as SHAPE-MaP, can reveal structural effects of mutations, especially when these data are incorporated into structure modeling. Here, we analyze the ability of SHAPE-MaP to detect the relatively...

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Identifiers

PMID: 29317542
DOI: 10.1261/rna.064469.117
PMCID: PMC5855952

Genes

LCP1
TPT1

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