RNA structure analyzed by chemical probing and mutational profiling with sequencing (MaPseq).

Abstract excerpt

RNA chemical probing, coupled with mutational profiling read out by sequencing (MaPseq), is a powerful approach for investigating the folding properties of complex RNA molecules. For over half a century, structure probing methods have advanced our understanding of the diverse functions of cellular RNAs. Depending on the analytical goal, these methods can generate models that reflect either the ensemble average...

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