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Article

Structural determinants for alternative splicing regulation of the MAPT pre-mRNA.

RNA biology - 1 Jan 2015

Lisowiec Jolanta, Magner Dorota, Kierzek Elzbieta, Lenartowicz Elzbieta, Kierzek Ryszard

Abstract excerpt

Alternative splicing at the MAPT gene exon 10 yields similar levels of the 3R and 4R tau protein isoforms. (1) The presence of mutations, particularly in exon 10 and intron 10-11, changes the quantity of tau isoforms. Domination each of the isoform yields tau protein aggregation and frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). Here, we report for the first time the secondary...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25826665
DOI: 10.1080/15476286.2015.1017214
PMCID: PMC4615681

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural determinants for alternative splicing regulation of the MAPT pre-mRNA.PMID 25826665Read ↗

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