Article
Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing.
American journal of human genetics - 5 May 2016
Yang Lixing, Lee Mi-Sook, Lu Hengyu, Oh Doo-Yi, Kim Yeon Jeong, Park Donghyun, Park Gahee, Ren Xiaojia, Bristow Christopher A, Haseley Psalm S, Lee Soohyun, Pantazi Angeliki, Kucherlapati Raju, Park Woong-Yang, Scott Kenneth L, Choi Yoon-La, Park Peter J
Abstract excerpt
Although exome sequencing data are generated primarily to detect single-nucleotide variants and indels, they can also be used to identify a subset of genomic rearrangements whose breakpoints are located in or near exons. Using >4,600 tumor and normal pairs across 15 cancer types, we identified over 9,000 high confidence somatic rearrangements, including a large number of gene fusions. We find that the 5' fusion...
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