Article

Phospho-signalling deregulation of the mTOR pathway in fibroblasts from LRRK2 Parkinson’s patients

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Activating mutations at the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most frequent genetic cause of Parkinson’s Disease (PD). Using in-depth mass-spectrometry, here we analysed the impact of LRRK2 mutations on the proteome and phospho-proteome of skin fibroblasts from a large LRRK2 clinical cohort from Spain. The cohort encompassed G2019S LRRK2-associated PD (L2PD) (n=15), G2019S LRR...

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Literature Corpus work: 125b1453-fc73-57cc-b445-8a448d9f8ce6
DOI: 10.64898/2025.12.05.692089

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