Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Phospho-Signatures in Blood Cells Identify LRRK2 G2019S Carriers in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 May 2022

Garrido Alicia, Santamaría Enrique, Fernández-Irigoyen Joaquín, Soto Marta, Simonet Cristina, Fernández Manel, Obiang Donina, Tolosa Eduardo, Martí María-José, Padmanabhan Shalini, Malagelada Cristina, Ezquerra Mario, Fernández-Santiago Rubén

Abstract excerpt

BACKGROUND: The clinicopathological phenotype of G2019S LRRK2-associated Parkinson's disease (L2PD) is similar to idiopathic Parkinson's disease (iPD), and G2019S LRRK2 nonmanifesting carriers (L2NMCs) are at increased risk for development of PD. With various therapeutic strategies in the clinical and preclinical pipeline, there is an urgent need to identify biomarkers that can aid early diagnosis and patient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterozygote
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Mutation

Share to Parkinson Disease

Share to Proteomics

Source

Open in PubMed Open full text

Identifiers

PMID: 35049090
DOI: 10.1002/mds.28927
PMCID: PMC9306798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Phospho-Signatures in Blood Cells Identify LRRK2 G2019S Carriers in Parkinson's Disease.PMID 35049090Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s diseaseSemantic proximity Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’sSemantic proximity Read ↗

Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.Semantic proximity Read ↗

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 CohortsSemantic proximity Read ↗

Phospho-signalling deregulation of the mTOR pathway in fibroblasts from LRRK2 Parkinson’s patientsSemantic proximity Read ↗

Changes in the cerebrospinal fluid proteome precede and stratify the course of Parkinson’s DiseaseSemantic proximity Read ↗

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s diseaseSemantic proximity Read ↗

Comparative blood transcriptome analysis in idiopathic and LRRK2 G2019S-associated Parkinson's disease.Semantic proximity Read ↗

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s diseaseSemantic proximity Read ↗

Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers of <i>LRRK2</i> -Linked Parkinson’s Disease ProgressionSemantic proximity Read ↗

Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson DiseaseSemantic proximity Read ↗

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.