Article
Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.
Human molecular genetics - 15 Dec 2016
Islam Md Shariful, Nolte Hendrik, Jacob Wright, Ziegler Anna B, Pütz Stefanie, Grosjean Yael, Szczepanowska Karolina, Trifunovic Aleksandra, Braun Thomas, Heumann Hermann, Heumann Rolf, Hovemann Bernhard, Moore Darren J, Krüger Marcus
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Parkinson`s disease (PD) and variation at the LRRK2 locus contributes to the risk for idiopathic PD. LRRK2 can function as a protein kinase and mutations lead to increased kinase activity. To elucidate the pathophysiological mechanism of the R1441C mutation in the GTPase domain of LRRK2, we expressed human wild-type or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.