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Article

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

2021-11-05

Abstract excerpt

Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and approaches have been utilized including assessments of LRRK2 itself (levels, phosphorylation), or its substrates (e.g. Rab10 or other Rab GTPases). We have previously shown that intrinsic kinase activity of LRRK2 isolated from PBMCs of G2...

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Literature Corpus work
a34389d5-3220-523d-8396-879ae9c303ad
DOI
10.1101/2021.11.05.465894
Open publication

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Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohortsDOI 10.1101/2021.11.05.465894
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