Article

Probing the proteome-wide impact of inhibitors of Leucine-rich Repeat Kinases 1 and 2 on protein-protein interactions and phosphorylation

2025-09-07

Abstract excerpt

The Leucine-rich repeat kinases 1 and 2 (LRRK1 and 2) are large, multidomain proteins and closely related members of the Roco protein family. They share a high similarity in domain structure and are both phosphorylate members of the Rab GTPase family. However, despite these similarities, there are substantial differences between the two kinases. While mutations to LRRK1 are only implicated in rare cases of osteope...

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Literature Corpus work: aaf4d6d7-5c7a-54d0-8a7b-cb24940e5b38
DOI: 10.1101/2025.09.03.674114

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