Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.

doi:10.1002/alz.70014

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Article

Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2025

D'Aoust Tim, Clocchiatti-Tuozzo Santiago, Rivier Cyprien A, Mishra Aniket, Hachiya Tsuyoshi, Grenier-Boley Benjamin, Soumaré Aïcha, Duperron Marie-Gabrielle, Le Grand Quentin, Bouteloup Vincent, Proust-Lima Cécile, Samieri Cécilia, Neuffer Jeanne, Sargurupremraj Muralidharan, Chêne Geneviève, Helmer Catherine, Thibault Mura, Amouyel Philippe, Lambert Jean-Charles, Kamatani Yoichiro, Jacqmin-Gadda Hélène, Tregouët David-Alexandre, Inouye Michael, Dufouil Carole, Falcone Guido J, Debette Stéphanie

Abstract excerpt

INTRODUCTION: An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high-risk individuals and improve risk prediction. METHODS: We developed an iPRS for dementia (iPRS-DEM) in Europeans (aged 65+), comprising genetic risk for Alzheimer's disease (AD) and 23 vascular or neurodegenerative traits (excluding apolipoprotein E [APOE]). iPRS-DEM...

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PMID: 40042447
DOI: 10.1002/alz.70014
PMCID: PMC11881617

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APOE

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