Article

Maternal diabetes causes embryonic cranial neural tube defects is associated with elevated H3K18cr and reduced AKT/PIKFYVE

2026-08-16

Abstract excerpt

Neural tube defects (NTDs) are severe congenital malformations resulting from incomplete neural tube closure during embryogenesis, with maternal diabetes mellitus being a well-established risk factor. However, the underlying epigenetic mechanisms remain poorly understood. In this study, we established a maternal diabetes mouse model by intraperitoneal injection of streptozotocin at embryonic day (E) 5.5 and examin...

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Literature Corpus work: 1221452c-aa57-556e-9b38-1fc6434ce3c5
DOI: 10.1186/s13072-026-00697-8

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