Article
Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Molecular and cellular biology - 1 Jan 2008
Menheniott Trevelyan R, Woodfine Kathryn, Schulz Reiner, Wood Andrew J, Monk David, Giraud Andrew S, Baldwin H Scott, Moore Gudrun E, Oakey Rebecca J
Abstract excerpt
By combining a tissue-specific microarray screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11. Ddc_exon1a is a 2-kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript and is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight...
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