Article

Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA

2025-03-16

Abstract excerpt

<h4>Summary</h4> The use of assisted reproductive technologies (ART) has enabled the birth of over 9 million babies; but it is associated with increased risks of negative metabolic outcomes in offspring. Yet, the underlying mechanism remains unknown. Calcium (Ca 2+ ) signals, which initiate embryo development at fertilization, are frequently disrupted in human ART. In mice, abnormal Ca 2+ signals at fertilizati...

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Literature Corpus work: f9169ae0-a174-5eed-ac34-15664fcae3f9
DOI: 10.1101/2025.03.14.643362

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