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Diabetes and Early Development: Epigenetics, Biological Stress, and Aging

29 Aug 2024

Abstract excerpt

Pregestational diabetes, either type 1 or type 2 diabetes, induces structural birth defects including neural tube defects and congenital heart defects in human fetuses. Rodent models of type 1 and type 2 diabetic embryopathy have been established and faithfully mimic human conditions. Hyperglycemia of maternal diabetes triggers oxidative stress in the developing neuroepithelium and the embryonic heart leading to...

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PMID: 39209306
DOI: 10.1055/a-2405-1493

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