Article

Hedgehog-induced-oxidative-phosphorylation rescues neuronal differentiation defect of human enteric neural crest cells underlying Hirschsprung disease

2022-04-08

Abstract excerpt

<title>Abstract</title> <p>Hirschsprung disease (HSCR) is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells (ENCCs), leading to intestinal obstruction. Here, using iPSC-based models of HSCR and single-cell transcriptomic analysis, we identified a core gene set of 118 genes commonly dysregulated in all HSCR-ENCCs, with <italic>HDAC1</italic> found to be a master re...

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Literature Corpus work: 296ab253-a2e7-5782-95d6-05c5f71f3237
DOI: 10.21203/rs.3.rs-1433241/v1

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