Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

doi:10.1093/hmg/ddz254

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Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.

Human molecular genetics - 15 Dec 2019

Poeta Loredana, Padula Agnese, Attianese Benedetta, Valentino Mariaelena, Verrillo Lucia, Filosa Stefania, Shoubridge Cheryl, Barra Adriano, Schwartz Charles E, Christensen Jesper, van Bokhoven Hans, Helin Kristian, Lioi Maria Brigida, Collombat Patrick, Gecz Jozef, Altucci Lucia, Di Schiavi Elia, Miano Maria Giuseppina

Abstract excerpt

A disproportional large number of neurodevelopmental disorders (NDDs) is caused by variants in genes encoding transcription factors and chromatin modifiers. However, the functional interactions between the corresponding proteins are only partly known. Here, we show that KDM5C, encoding a H3K4 demethylase, is at the intersection of transcriptional axes under the control of three regulatory proteins ARX, ZNF711 and...

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PMID: 31691806
DOI: 10.1093/hmg/ddz254
PMCID: PMC7002875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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