Article

Increased ATP citrate lyase affects maternal diabetes-induced neural tube defects by promoting the H3K27ac modification through the Gadd45g pathway

2022-05-02

Abstract excerpt

<title>Abstract</title> <p>Diabetes mellitus (DM) in early pregnancy increases the risk of neural tube defects (NTDs) in offspring. Enzyme-regulated histone acetylation has been reportedly linked to this pathological process. Few studies have focused on the intermediate acetyl-CoA, a substrate source of histone acetylation modification in maternal DM-induced NTDs. Here, we report that ATP citrate lyase (Acl), a m...

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Literature Corpus work: 26d85fa8-eb33-5319-a86a-1e7f21a099db
DOI: 10.21203/rs.3.rs-1546141/v1

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