Article

Increased ACL impacts maternal diabetes induced neural tube defects by promoting modification of H3K27ac through Gadd45g pathway

2022-04-06

Abstract excerpt

<title>Abstract</title> <p>Diabetes mellitus (DM) in early pregnancy increases the risk of offspring neural tube defects (NTDs). Enzymes regulated histone acetylation has been reported lin ked to this pathogenic process. While few studies focus on the intermediate acetyl-CoA, a substrate source of histone acetylation modification to maternal DM induced NTDs. Here, by using HPLC-MS/MS, western blot (WB) et al., te...

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Literature Corpus work: 4543a4d8-c704-5c50-9817-ca1750b7afd6
DOI: 10.21203/rs.3.rs-1477815/v1

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