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Article

Responses of the embryonic epigenome to maternal diabetes

11 Jul 2012

Abstract excerpt

Maternal diabetes and obesity are independent risk factors for neural tube defects, although it is unclear whether the effects are mediated by common pathogenic mechanisms. In this manuscript, we report a genome-wide survey of histone acetylation in neurulation stage embryos from mouse pregnancies with different metabolic conditions: maternal diabetes, and maternal consumption of a high fat content diet. We find...

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PMID: 22786762
DOI: 10.1002/bdra.23035

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