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α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology.

Cell reports - 11 May 2021

Stykel Morgan G, Humphries Kayla M, Kamski-Hennekam Evelyn, Buchner-Duby Brodie, Porte-Trachsel Natalie, Ryan Tammy, Coackley Carla L, Bamm Vladimir V, Harauz George, Ryan Scott D

Abstract excerpt

Neuronal loss in Parkinson's disease (PD) is associated with impaired proteostasis and accumulation of α-syn microaggregates in dopaminergic neurons. These microaggregates promote seeding of α-synuclein (α-syn) pathology between synaptically linked neurons. However, the mechanism by which seeding is initiated is not clear. Using human pluripotent stem cell (hPSC) models of PD that allow comparison of SNCA mutant...

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PMID: 33979611
DOI: 10.1016/j.celrep.2021.109099

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