Article

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson’s Disease

2026-04-07

Abstract excerpt

The aggregation of α-synuclein (α-SYN) into Lewy bodies (LBs) is a central event in the pathogenesis of Parkinson’s disease (PD) and related synucleinopathies 1,2 . Despite significant advances in understanding α-SYN self-assembly, the precise sequence of early aggregation steps has not been directly visualized in living neurons. Here, we use an optogenetic-induced protein aggregation system with a high temporal...

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Literature Corpus work: 76255e8f-3dc2-5d29-af89-1e3d2e3f18d4
DOI: 10.64898/2026.04.03.716340

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