Article

Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease

2025-02-16

Abstract excerpt

Intercellular transmission of α-synuclein contributes to Parkinson’s disease pathology. Yet, the mechanisms of α-synuclein spread are not fully understood. Here, we used live-cell microscopy to examine the impact of Parkinson’s disease associated lipid alterations on α-synuclein release. We discovered that increased glucosylceramides induce ectosome shedding from primary neurons, and from dopaminergic neurons deri...

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Literature Corpus work: 06425cda-c4e8-59c2-a53f-a4b8c304c09d
DOI: 10.1101/2025.02.14.638390

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