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Article

Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging.

Journal of neurochemistry - 1 Jul 2008

Opazo Felipe, Krenz Antje, Heermann Stephan, Schulz Jörg B, Falkenburger Björn H

Abstract excerpt

Aggregates of alpha-synuclein are the pathological hallmark of sporadic Parkinson's disease (PD), and mutations in the alpha-synuclein gene underlie familial forms of the disease. To characterize the formation of alpha-synuclein aggregates in living cells, we developed a new strategy to visualize alpha-synuclein by fluorescence microscopy: alpha-synuclein was tagged with a six amino acid PDZ binding motif and...

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Identifiers

PMID: 18410502
DOI: 10.1111/j.1471-4159.2008.05407.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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