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Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant <i>Streptococcus pneumoniae</i>

2024-10-30

Abstract excerpt

Streptococcus pneumoniae is a human pathogen that has become increasingly resistant to the synthetic fluoroquinolone antibiotics that target bacterial topoisomerases. To identify pathways that are essential under fluoroquinolone stress and thus might represent novel targets to revitalize the use of this class of antibiotics, we performed genome-wide CRISPRi-seq screens to determine antibiotic-gene essentiality sig...

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Identifiers and source

Literature Corpus work
11b09f77-d1f7-5a6c-bacc-7104f848f13b
DOI
10.1101/2024.10.30.621020
Open publication

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Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant <i>Streptococcus pneumoniae</i>DOI 10.1101/2024.10.30.621020
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