Article

Exploring the genetic landscape of ciprofloxacin-induced DNA supercompaction in <i>Escherichia coli</i>

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> DNA-damaging antibiotics like ciprofloxacin induce extensive double-strand breaks in Escherichia coli , triggering the SOS response and leading to DNA supercompaction. To uncover genes involved in this process beyond the previously identified core factors of recN and recA , we conducted a genome-wide screening using high-content imaging and machine learning-assisted image classification on ne...

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Literature Corpus work: c5c8c6b8-6df7-5d0c-a273-cbecbad987c2
DOI: 10.1101/2025.07.12.663469

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